The closer the player gets to the target area, the more accurate the pitch or throw will be. In MVP Baseball, the player first holds down the pitch button (or throw button) to judge the power once the desired power level is attained, the player must release the button and attempt to tap the same button within a target area. Until then, most baseball games' pitching schemes required players simply to press the button corresponding to the pitch they wanted to throw, and hold the button down for a certain length of time to determine how hard the pitch was thrown. Upon its release in 2003, one of the game's most inventive aspects was its pitch/throw meter. However, the college baseball game did not fare well, and was not produced after 2007. As a result, the MVP Baseball series featured college baseball, with MVP 06 NCAA Baseball having been released in late January 2006, and MVP 07: NCAA Baseball in February 2007. The agreement, which runs from Spring 2006 to 2012, allows for the console manufacturers Sony, Microsoft, and Nintendo to produce MLB titles for their respective platforms, but bars third party developers such as EA Sports from continuing or developing their own MLB games. In 2005, in response to EA Sports' exclusive license with the National Football League and ESPN, Take-Two Interactive signed an exclusive third-party licensing contract with Major League Baseball (MLB), MLBPA and MLBAM to produce MLB games.

Randy Johnson has also won the Cy Young Award five times.

Of those four, Tejada and Pujols have won Most Valuable Player (MVP) awards during their careers, and the other two have been named MVPs of the World series. Various editions of the game have featured Randy Johnson, Miguel Tejada, Albert Pujols, and Manny Ramírez on its cover. MVP Baseball 2004 featured a unique addition to any baseball game, allowing users to play as the Minor League affiliations of Major League teams, a feature that was expanded in the following year. In MVP Baseball 2005, he was replaced by the fictional Anthony Friese. For example Kevin Millar, who is also not a member of the MLBPA, was omitted completely from the 2004 edition, with David Ortiz leaving his real-life DH spot and filling at first base for the Red Sox. Some other players who are not members of the MLBPA were omitted completely. Until 2005, the game featured all players in the Major League Baseball Players Association (MLBPA), as well as fictionalized counterparts for players who are not in the union, such as Jon Dowd in place of Barry Bonds.

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